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免疫教研室科研成果及奖励

获奖项目

获奖级别

主要获奖者

获奖年度

缺血再灌注心肌细胞凋亡机制及防治的研究

天津市科技进步三等奖

卢奕

2003

长效白细胞介素-6的研制

天津市科技进步二等奖

姚智

2003

IL-1ra在脑创伤中的作用

天津市科技进步三等奖

姚智

2002

HCG免疫调节作用的系列研究

天津医科大学科技成果一等奖

白虹

2002

IL-1IL-6TNFα基因在卵巢癌患者PBMC及肿瘤细胞中的表达

天津市科技进步三等奖

卢奕

2000

IL-6基因在真核细胞中的高效表达

天津市科技进步三等奖

姚智

1997

大肠癌组织中免疫抑制因子的测定和临床病理分期的关系

天津市科技进步三等奖

白虹

1995

 

免疫教研室承担的主要科研项目及获得科研经费情况

序号

项目名称

负责人

立项

时间

完成

时间

项目来源

经费

(万)

1

水分子族结构及其振转运动对生命大分子活性的影响及调控机理

 

2003

2006

973前期专项

135

2

酪丝亮肽抗肿瘤作用及机制研究

 

2004

2006

863第一承担单位

800

3

新型抗肿瘤药物AGPM的体外细胞毒性研究

 

2003

2004

863(子项目)

20

4

sRANK-FcNF-KB在乳腺癌骨转移中的作用

 

2005

2006

国家自然科学基金

8

5

抗肿瘤新药CMS多肽抗肿瘤机制的研究

 

2003

2006

教育部重点项目

2

6

升血小板药物白介素-11的研制

 

2000

 

2004

市科委重大攻关项目

80

7

白细胞介素-11的中试研究

 

2003

 

2006

市科委重大科技攻关

80

8

重组人白细胞介素-6的研制

 

2001

2004

市科委攻关项目

50

9

长效细胞因子的研制

 

2003

2005

市科委攻关项目

30

10

抗肿瘤药物的研制与筛选

 

2001

 

企业基金

170

11

人类疾病诊断试剂盒的研制

 

2001

 

英捷科研基金

30

12

细胞因子与骨代谢

 

2002

 

美国NIH子课题

75

13

有关STAT6信号传导通路调控机制的研究

 

2004

2006

国家自然科学基金

20

14

有关STAT6信号传导通路调控机制的研究

 

2004

2005

国家自然科学基金国际合作交流

2.3

15

新世纪人才支持计划

 

2005

2007

国家教育部

50

16

STAT6转录调控分子机制的研究

 

2005

2007

教育部留学回国基金

2

17

STAT6转录调控复合物的组成和功能

 

2005

2007

博士学科点专项基金

3

18

JAK-STAT6信号传导通路的调控机制及哮喘的治疗

 

2004

2006

天津市科委应用基础研究重点项目

15

19

遗传因素对食物过敏的影响

 

2005

2006

天津市科委国际合作项目

10

20

婴幼儿食物过敏和环境及遗传因素的影响

 

2004

2006

科技部中芬政府间科技合作项目

自筹

21

运动/肌肉收缩调节骨骼肌GLUT4转位和活性机制研究

牛文彦

2006

2008

国家自然科学基金

24

22

p38MAPK对葡萄糖转运子4的作用

牛文彦

2004

2006

天津市教委

3

23

VEGFMMPs/TIMPs再前列腺癌发生发展中作用的研究

 

2003

 

2005

天津市科委

自筹

24

沙眼衣原体感染小鼠易感性差异的研究

 

2004

 

2006

天津市自然科学基金

6

25

激活素介导巨噬细胞分泌

张学军

2005

2007

天津市教委

3

26

巨噬细胞淍亡调控机制的研究

张学军

2006

2008

教育部重点项目

2

27

卵巢癌干细胞的分离和鉴定

邓为民

2006

2008

天津市自然科学基金

8

28

PAFT细胞早期活化信号传导的调节

王金龙

2001

2003

天津市自然科学基金

6

29

同型半胱氨酸的免疫学测定技术

王金龙

2002

2005

天津市自然科学基金

自筹经费

30

雌性激素对甲状腺炎发生的影响

王金龙

2003

2005

天津市自然科学基金

6

免疫教研室近五年发表的主要SCI论文

 作为第一作者发表的SCI收录文章

序号

文章名称

第一作者

期刊名称

收录日期

1

Tripeptide tyroserleutide enhances the antitumor effects of macrophages and stimulates macrophage secretion of IL-1β, TNF-α, and NO in vitro

 

Cancer Immunology Immunotherapy.

2005

2

The effect of tripeptide tyroserleutideYSLon animal models of hepatocarcinoma

 

Peptide.

2005

3

Ethanol activates NFκB DNA  binding and p56lck protein tyrosine kinase in human  osteoblast-like cells.

 

Bone

2001

 4

The transcriptional co-activator protein p100 recruits HAT activity to STAT6 and mediates interaction between CBP and STAT6.

 

J. Biol. Chem

2005

5

Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.

 

EMBO J

2002

6

IκBα super-repressor inhibits H2O2-induced interleukin-6 (IL-6) expression through inactivation of NFkB in myotubes.

 

Gerontologist

2002

7

Extract From Scutellaria baicalensis Georgi(Huang Qin) Induces Prostate Cancer Cell Apoptosis and Diminishes the Tumor Growth in Murine Bone.

 

Journal of Bone and Mineral Research

2002

8

Osteoblasts induce prostate cancer proliferation and PSA expression through interleukin-6-induced activation of the androgen receptor.

 

Clin Exp Metas

2004

9

Allogeneic Bone Marrow Derived Flk-1+Sca-1- Mesenchymal Stem Cells Leads to Stable Mixed Chimerism and Donor-Specific Tolerance

邓为民

Exp Hematol.

2004

10

Flk-1+ bone marrow derived mesenchymal stem cells engrafted into skin regenerate skin tissue.

邓为民

Tissue Engineering.

2004

11

Long-term distribution of allogeneic adult stem cells in recipient tissues after transplantation

邓为民

Stem Cell and Cellular Therapy

2003

12

Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocyte from BXSB mice.

邓为民

DNA and Cell Biology.

In press

 13

 

Intranasal inoculation of Chlamydia trachomatis mouse pneumonitis agent(MoPn) induces significant neutrophil infiltration which is not efficient in controlling the infection in mice.

 

Immunology

2004

14

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis.

牛文彦

J Biol Chem.

2003

  合作发表的SCI收录文章

序号

文章名称

作者

期刊名称

收录日期

1

In Vivo Real-Time Imaging of TGF-β- Induced Transcriptional Activation of the RANK Ligand Gene Promoter in Intraosseous Prostate Cancer

 

姚智

 

Prostate

 

2004

2

Vascular endothelial growth factor contributes to the prostate cancer- induced osteoblast differentiation mediated by bone morphogenetic protein

 

姚智

 

Cancer Res

 

2004

3

In Vivo Visualization of Aging- associated Gene Transcription: Evidence for Free Radical Theory of Aging

 

姚智

Experimental Gerontology

 

2004

4

Changes of interleukin-1 beta, tumor necrosis factor alpha and interleukin-6 in brain and plasma after brain injury in rats.

 

姚智

 

Chin.J Traumatol

 

2004

5

Soluble Receptor Activator of Nuclear Factor κB Fc Diminishes Prostate Cancer Progression in Bone.

姚智

Cancer Res

 

2003

6

In vivo imaging of TGFβ-induced RANK ligand transcriptional activation in prostate cancer

姚智

J BONE MINER RES

2003

7

Soluble Receptor Activitor of Nuclear Factor kB Fc Diminishes Prostate Cancer Progression in Bone.

 

姚智

 

Cancer Research.

 

2003

8

Osteoprotegerin abrogates chronic alcohol ingestion-induced bone loss in mice

姚智

J Bone Miner Res.

2002

9

Applications of high-throuhput methods to cancer methods to cancer metastases.

姚智

J Musculoskel Neuron Interact

2002

10

The influence of sex hormones on circulating nitric oxide(Nox) level in Rhesus Monkey(Macaca Mulatta)

 

姚智

 

Med.Sci Monit.

 

2002

11

The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus  monkey (Macaca mulatta) model of menopause.

 

姚智

 

J.Repro Immunol.

 

2001

12

Interleukin-6 Induces Androgen Responsiveness in Prostate Cancer Cells Through Up-regulation of Androgen Receptor Expression

 

姚智

Clinical Cancer Research

 

2001

13

Molecular basis of Stat1 and PU.1 cooperation in cytokine-induced Fc gamma receptor I promoter activation

 

杨洁

 

Int Immunol.

 

2004

14

PIAS proteins promote SUMO-1 conjugation to STAT1.

杨洁

Blood

2003

15

Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5.

 

杨洁

 

Mol Endocrinol.

 

2003

16

 

 

Distinct functions for signal transducer and activator of transcription 1 and PU.1 in transcriptional activation of Fc gamma receptor I promoter.

 

 

杨洁

 

 

Blood

 

 

2002

17

Less Inhibition of IFN-γ to Organism Growth in Host Cells May Contribute to the High Susceptibility of C3H Mice to Chlamydia trachomatis Lung Infection

 

 

白虹

 

 

Immunology

 

 

2004

18

Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity.

 

牛文彦

Endocrinology

 

2005

19

To be or not to be:Regulation of the Intrinsic activity of Gult4

 

牛文彦

Curr. Med. Chem- Immun., Endoc.

 

2005

20

Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues.

 

牛文彦

 

Diabetologia.

 

2003

21

Maturation of Insulin-Dependent Gulcose Transport and p38 MAPK Activation during Differentiation of L6 Muscle Cells

 

牛文彦

 

Diabetes

 

2002

             作为通讯作者发表的SCI收录文章

序号

文章名称

作者

期刊名称

收录日期

1

Expression of PTEN, p27, p21 and AKT mRNA and protein in human BEL-7402 hepatocarcinoma cells in tranaplanted tumors of nude mice treated with the tripeptide tyroservatide(YSV)

姚智

Int J Cancer.

 

2006

2

Experimental study of the inhibition of human hepatocarcinoma Bel7402 cells by the tripeptide tyroserleutideYSL

姚智

Cancer Chemotherapy and Pharmacology

2005

3

Gene-chip analysis of the effect of tripepetide tyroservatide(YSV) on gene-expression in human hepatocarcinoma BEL-7402 tumors transplanted to nude mice

姚智

Mol Carcinog.

2005

4

Tyroserleutide tripeptide affects calcium homeostasis of human hepatocarcinoma BEL-7402 cells

姚智

Sci China C life Sci.

2005

5

Preliminary investigation of the inhibitory effect of the tyroservaltide tripetide on human hepatocarcinoma BEL-7402

姚智

Cancer Biol Ther.

2005

 

 


 
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