课程名称：Pathology    课程内容：细胞和组织的损伤与适应 CELL INJURY AND ADAPTATION

教师姓名：张乃鑫    职称：教授   教学日期：2005年下学期

授课对象：七年制    教材版本：病理学（卫生部规划教材七年制 第一版）          

授课方式：大课      学时数：4学时    听课人数： 90    人

本单元或章节的教学目的与要求： 

1.CELL  INJURY

(1)Pathogens

(2) Pathogenesis: Membrane damage, Hypoixia, Activated oxygen species (free radicals) Free calcium within cytoplasm, Chemical subtance & drugs, Genetic  variation

(3)Degeneration: ①Concept, ②Patterns

(4)Cell death

  ①Apoptosis

  ②Fibrinoid necrosis

  ③Necrosis: Concept, Morphology, Parttens, Consequances

2.ADAPTATION

(1)Hypertrophy

(2)Hyperplasia

(3)Atrophy

(4)Metaplasia

授课主要内容及学时分配：

1. CELL  INJURY (150mins)

(1) Pathogens & Pathogenesis(30mins)

(2) Degeneration(70mins)

(3) Cell death(50mins)

2. ADAPTATION(30mins)

重点：难点及对学生要求（包括掌握、熟悉、了解、自学）

Understanding

 The Pathogenesis of the cell injury

 The Degeneration: Concept & Patterns

 The Cell death: Apoptosis,Fibrinoid necrosis,Necrosis:

 The Adaptation: Patterns

外语词汇：

Cell injury  Adaptation  Degeneration  Cell death  Pathogens  Hypoxia  Aging

Genetic  Pathogenesis  Membrane damage  Activated oxygen species  free radicals

Genetic variation  Accumulation of subtances  Glycogen accumulation 

Lysosomal storage disease  Cellular swelling  Hydropic degeneration  Fatty change

Fatty degeneration  Hyaline degeneration  Hyaline change  Mucoid degeneration

Hypothyroidism  Amyloidosis  Pathological pigmentation  Pathological calcification  Arteriolosclerosis Myxedema of skin  Dystrophic calcification  Metastatic calcification

Carbon deposit  Hemosiderin  Lipofuscin  Melanine  Addison’s disease  Bilirubin

Cholestasis  Jaundice  programmed death  Autolysis  Coagulation Necrosis

Dry gangrene  Moist gangrene  Gas gangrene  Caseous necrosis

Liquefactive necrosis  Encephalomalasia  Fat Necrosis  Ulcer  Sinus  Fistular

Concentric hypertrophy of heart

辅助教学情况：

CAI

复习思考题：  

1.The pathogens and pathogenesis of the cell injuru

2.The concept and patterns of the degeneration

3.The concept, mechanism and significances of the apoptosis

4.The concept, morphology and significances of the fibrinoid necrosis

5.The concept, morphology, parttens, and consequances of necrosis

6.The patterns and tuire morphology of adaptation

参考资料：

Cotran RS, Kumar V, Collins T. Pathologic Basis of Disease.