课程名称：Pathology    课程内容：胃肠道疾病  DISEASE  of  GASTROINTESTINAL TRACT

教师姓名：仇晓菲    职称：副教授   教学日期：2005年下学期

授课对象：七年制    教材版本：病理学（卫生部规划教材七年制 第一版）          

授课方式：大课      学时数：4学时    听课人数： 90    人

本单元或章节的教学目的与要求： 

After completion of the part of this chapter, students are required to be familiar with the etiology, pathogenesis, pathologic changes and clinical-pathological correlations of the common diseases of the gastrointestinal tract. Moreover, they should have mastered those pathologic changes related to the clinical diagnosis, treatment and prognosis. They should also understand the advancement of this fields.

The aim of our teaching is to make students to have a deep understanding of the key concepts and intrinsic properties of the diseases of GI tract in order to lay the pathological groundwork for their future clinical practice and research work.

授课主要内容及学时分配：

Esophagitis, 10 min.

Gastritis, 30min.

Peptic ulcer, 30min.

Appendicitis, 10min.

Crohn’s disease, 25min.

Ulcerative colitis, 25min.

Carcinoma of esophagus, 35min.

Carcinoma of stomach 35min.

Carcinoma of large intestine, 35min.

Other tumors 15min.

重点：难点及对学生要求（包括掌握、熟悉、了解、自学）

The stress we should put on includes

1.The pathologic characteristics of chronic atrophic gastritis

2.The pathologic changes and complication of the peptic ulcer of stomach

3.The pathologic characteristics of all types of appendicitis

4.The pathologic changes and complication of Crohn’s disease and ulcerative colitis

5.The classification, pathologic changes and clinical-pathologic correlations of carcinoma of esophagus, carcinoma of stomach and colonic carcinoma

外语词汇：Reflux esophagitis, Barrett’s esophagus esophageal carcinoma, Inflammatory Bowel Disease (IBD), Pyloric stenosis, Chronic gastritis, Helicobacter pylori, Autoimmune gastritis Gastric carcinoma, intestinal variant, Atrophic gastritis, Diffuse gastric carcinoma, Intestinal metaplasia, Early gastric carcinoma, Gastric glandular dysplasia, Linitis plastica,Signet-ring cells, Peptic ulcer, Krukenberg tumor, Cholera Suppurative appendicitis, Gangrenous appendicitis, Crohn’s disease, Crypt abscess, Ulcerative colitis, Pyloric metaplasia, Regional enteritis, Transmural inflammation, Skip lesions, Pseudopolyps, Cobblestone pattern, Goblet cell depletion, Glandular dysplasia, Fissure, Fistula (sinus tract), Adenomatous polyp (tubular adenoma), Dukes staging, Familial adenomatous polyposis.

复习思考题：

1. What is Barret’s esophagus? What is its complication?

2. What is linitis plastica? What is early gastric carcinoma?

3. Write a short note on classification of chronic gastritis?

4. Write brief note on peptic ulcers? What are the common sites? Pathological changes and complication?

5. Write a brief note on the classification of gastric carcinoma?

6. Write a brief note on Duke's Classification?

7. Compare ulcerative colitis and Crohn's disease in terms of localization of the lesion, gross and microscopic changes. 

参考资料：

1.Kumar V, Cotran RS, Robbins SL. Basic Pathology 7th ed. Philadelphia:  WB Saunders, 2002.

2.Cotran RS, Kumar V, Collins T. Robbins Pathologic basis of Disease. 6th ed. Philadelphia: WB Saunders, 1999.

3.孙保存. 胃肠道. 见谭郁彬、张乃鑫主编. 外科诊断病理学. 天津：天津科技出版社, 2000,462-474

4.来茂德. 结直肠癌发生的分子机制研究. 中华病理学杂志. 2000,29:450-452

5. Stevens A, Lowe J. Pathology 2 th ed.London:Mosby,2000.