课程名称：Pathology    课程内容：淋巴造血系统疾病 DISEASES  OF  LYMPHOID AND HEMATOPOIETIC TISSUES / SYSTEM

教师姓名：张乃鑫    职称：教授      教学日期：2005年下学期

授课对象：七年制    教材版本：病理学（卫生部规划教材七年制 第一版）          

授课方式：大课      学时数：4学时    听课人数： 90    人

本单元或章节的教学目的与要求： 

1.Lymphoreticular Tissue: Structure and Function

(1)Transformation of lymphocytes

(2)Mucosa-associated lymphoid tissues (MALT)

(3)Lymph nodes

2.Malignant Lymphoma(ML)

(1)Introduction
(2)Hodgkin lymphoma (HL)
(3)Non-Hodgkin lymphoma (HL)

3.Myeloid Tumors

(1)Chronicmyeloproliferative diseases(CMPD)

(2)Myelodysplastic syndromes(MDS) 

(3)Acute myeloid leukemia(AML)

(4)Myeloid sarcoma (MS)

授课主要内容及学时分配：

1.Lymphoreticular Tissue: Structure and Function (30mins)

2.Hodgkin lymphoma (50mins)

3.Non-Hodgkin lymphoma(100mins)

4.Myeloid Tumors(60mins)

重点：难点及对学生要求（包括掌握、熟悉、了解、自学）

Understanding

The concepts of the transformation of lymphocytes, mucosa-associated  lymphoid tissues

The structure and functions of lymph nodes

The concept,classification,t and clinico-pathological relationship of the lymphoma

The concept,classification,t and clinico-pathological relationship of the myeloid tumors

外语词汇：

Lymphoid and hematopoietic system  Reactive hyperplasia  malignant：Lymphoma 

Transformation of lymphocytes  Mucosa-associated lymphoid tissues (MALT)

Lymph nodes  Follicle  Germinal center Marginal zonv  Paracortex  Mantle zone

Centroblasts  Centricities  Sinus  histiocytespPostcapillary venule(PCV) 

Hodgkin lymphoma (HL)  Non-Hodgkin lymphoma (NHL) 

Precursor B-and T-cell neoplasms  Mature B-cell neoplasms

Mature T-cell and NK-cell neoplasms  Indolent lymphoma  Aggressive lymphoma

Highly aggressive lymphoma  Histological Classification  Lymphadenopathy

Extra nodal  Reed-Sturnberg cell  Clssic Hodgkin’s Lymphoma

Nodular sclerosis (classical) HL(NSHL)  Mixed cellularity (classical) HL(MCHL)

Lymphocyte-rich (classical) HL(LRCHL)  Lymphocyte-depleted (classical) HL(LDHL)

Precursor B- and T-cell neoplasms  (Precursor B- and T-cell acute lymphocytic leukemia)

Mature B-cell neoplasms  Mature T-cell and NK-cell neoplasms

Diffuse large B-cell lymphoma  Burkitt’s lymphoma  Peripheral T-cell lymphoma

Extranodal NK/T cell lymphoma, nasal type  (Acute) Lymphoblastic leukemia / lymphoma

Chronic lymphocytic leukemia / small lymphocytic lymphoma  

Marginal zone B-cell lymphoma  MALT Lymphoma  Plasma Cell Neoplasms

Follicular Lymphoma  Mantal Cell Lymphoma  Diffuse Large B-cell Lymphoma

Burkitt Lymphoma  Peripheral T-cell lymphoma 

Chronic myeloproliferative diseases(CMPD)  Myelodysplastic syndromes(MDS) 

Acute myeloid leukemia(AML)  Myeloid sarcoma \(MS)

辅助教学情况：

CAI

复习思考题：  

1.The concepts of  the Lymphoreticular Tissue, Transformation of lymphocytes,

Mucosa-associated lymphoid tissues (MALT)

2.The concept,classification,t and clinico-pathological relationship of the lymphoma

3.The concept,classification,t and clinico-pathological relationship of the myeloid tumors

参考资料：

Cotran RS, Kumar V, Collins T. Pathologic Basis of Disease.