1.Objectives
Thyroid gland and clinical uses of thyroid hormone preparations.
Mechanism of actions of thyroid gland agents, clinical
uses, adverse effect and caution.
2.Teaching content
Review biochemistry and physiology of thyroid hormones:
synthesis, storage and secretion of thyroid hormone. Relationship
to hypothalamus and hypophysis. Action on growth and differentiation
of cells, on energy metabolism, clinical uses and adverse
effects.
Antithyroid agents:
(1)Thioureas: methylthiouracil, propylthiouracil, tapazole,
carbimazole.
Inhibition of peroxidase, blockage oxidation of iodide,
inhibition of iodination of tyrosine, blockage of synthesis
of thyroid hormone. Characteristics of each drug used
to treat hyperthyroidism. Adverse effects and caution.
(2)Iodine/Iodide: used to treat endemic goiter and hyperthyroidism.
Lugol’s solution: caution.
(3)Radioactive iodine: for diagnosis and therapy of hyperthyroidism.
Teaching hours: 2
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