1.Objectives
Pharmacological action, antimicrobial spectrum, indications,
adverse effects, and their prevention. Characteristics
of penicillin G, semi-synthetic penicillins and cephalosporins.
Development of penicillins and cephalosporins.
2.Teaching content
Physical and chemical property of penicillin G, antimicrobial
spectrum, mechanism of action, characteristic pharmacokinetics
and routes of administration, bacteria resistance，allergy,
and its prevention. Clinical uses. Long-acting mechanism
of procaine penicillin G and benzathine benzylpenicillin,
clinical evaluation.
Side chain binding to 6-aminopenicillanic acid forms semi-synthetic
penicillins. Beta-lactamase-resistant oxacillins can be
used to treat infection caused by resistant staphylococci.
Characteristics and clinical uses of extended spectrum
penicillin, aminobenzylpenicillin, carbenicillin and antipseudomonal
extended spectrum penicillins.
Side chain binding to 7-aminocephalosporanic acid forms
semi-synthetic antibioltics.
Chemical structure and pharmacological actions are similar
to those of benzylpenicillin，antimicrobial spectrum is
extensive, commonly used cephalosporin: first-generation
cephalosporin, second-generation cephalosporin, third-generation
cephalosporin. Characteristics and clinical uses of different
drugs.
Teaching hours: 3
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