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Teaching
Syllabus for Pharmacology --Back--
（Program for 7-Year Students, School
of Medicine）
Chapter 31 Antidiabetic Drugs
1.Objectives
Mechanism of action of insulin and oral hypoglycemic agents.
clinical uses. and caution.
2.Teaching content
Review biochemistry of insulin. Enhancement of glycogenesis
and glycolysis, regulation of carbohydrate metabolism.
Insufficiency of insulin results in diabetes. Substitution
therapy.
Dose principle: short-acting insulin (regular insulin);
intermediate-acting insulin (insulin zinc suspention amorphous);
long-acting insulin (insulin zinc suspension ), principle
for selection of drugs, adverse effects and caution.
Oral hypoglycemic agents:
Sulfonylureas: tolbutamide, chlorpropamide, glibenclamide.
Direct stimulation of insulin release from the B cell.
Treatment of patients suffering from typeⅡ diabetes.
Biguanides : hyperglycemia with refractory obesity and
combination with sulfonylureas for type Ⅱdiabetes.
Causation of lactic acidosis
Teaching hours: 2
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