1.Objectives
(1)Therapeutical principles of immunosuppressive agents,
main indications, adverse effects, characteristics of
commonly used immunosuppressive agents.
(2)Mechanism of anti-malignant tumor agents, indication
and adverse effects. Relationship between cell proliferation
cycle and cancer chemotherapy.
2.Teaching content
Overview: status of anti-malignant tumor agents on cancer
chemotherapy. cell proliferation kinetics and malignant
tumor chemotherapy.
Alkylating agents; cyclophosphamide, chlorambucil, formylmerphalan,
carmustine, thiophosphoramide, busulfan cross-links with
DNA and inhibits its replication.
Antimetabolites: Folic acid antagonist: methotrexate;
purine antagonist: mercaptopurine.
Pyrimidine antagonist: Fluorouracil; DNA synthesis antagonist:
cytarabine(ara-c), cyclo-C.
Antibiotics: actinomycin D, bleomycin mitomycin C, plicamycin,
daunorubicin, doxorubicin.
Plant alkaloids: vinblastine, vincristine, colchicine,
affect spindle formation. Camptothecine hydroxycamptothecin,
harringtonine.
Hormones: adrenal cortical hormone, androgen, estrogen.
Other agents: cisplatin and carboplatin, L-asparaginase,
interferon.
Selectivity of available cancer chemotherapy is not high,
causeing lesions to normal rapidly proliterating tissue.
High toxicity. The application is limited. Consideration
of the combination of drugs based on pharmacological principles.
Teaching hours: 3
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